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TheNerd's "KSP Mun or Bust!"
For those of you who aren't familiar with Kerbal Space Program (KSP), I'll give a brief description: KSP is an unfinished, ever developing PC game that can be bought from their website. The idea of the game is to create and manage your own space program, including Rockets, Space planes, Space stations, Moon buggies and Colonies.
I think that this game would make a great LEGO set because, like minecraft, Kerbal is extremely creative and endless so there is potential for infinite vehicle designs, MOC's, brickfilms and ultimately a lot of fun!
There are thousands of people that play KSP everyday and im sure they would all love a little LEGO Kerbal rocket and crew on their desk that they can fiddle about with.